GINSIX forte and Chemotherapy Induced Nausea and Vomiting (CINV).
Nausea and vomiting are side effects of cancer therapy and affect most patients receiving chemotherapy. Radiation therapy to the brain, gastrointestinal tract, or liver also causes nausea and vomiting.
Ginger contains a number of pungent constituents and active ingredients. The major pungent compounds in ginger are active gingerols, which can be converted to shogaols, zingerone, and paradol. The compound 6-gingerol appears to be responsible for its characteristic taste. Zingerone and shogaols are found in larger amounts in dried or extracted products.
Benefits of Ginger in CINV
- Antiemetic activity: Suppressing 5-HT receptor. Nausea and vomiting are complex responses involving various neural pathways and motor responses to sensory stimuli; however, ginger and its constituents seem to function peripherally, by blocking 5-HT3 receptors – and most likely have an effect on other (cholinergic, vanilloid) peripheral receptors involved in smooth muscle contraction in the gastrointestinal tract.
- Antioxidant activity: Nrf2 signalling pathway
- Anti-inflammatory Activity: pro-inflammatory and anti-inflammatory cytokines- PI3K/Akt and NF-kB signaling.
- Antimicrobial activity: Inhibiting biofilm formation. Affecting membrane integrity.
- Neuroprotection: Anti-neuroinflammatory. Upregulating the level of NGF.
Ginger may also have positive benefits in decreasing fatigue and non-GI adverse events during chemotherapy.
Vitamin B6, mainly in its form of biologically active coenzyme pyridoxal 5’-phosphate, is involved in a wide range of biochemical reactions, including amino acid and glycogen metabolism, nucleic acid synthesis, hemoglobin, sphingomyelin, and other sphingolipids. synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA). Vitamin B6 has been known to have antiemetic effects since 1942.
Focusing on Anticipatory Nausea and Vomiting (ANV).
Anticipatory CINVs are generally considered to be a conditional response to a previous episode of CINV. A sensory stimulus (e.g., sight, hearing, smell) present at the time of an CINV episode conditions the patient to associate the stimulus with nausea and vomiting.
Post-stimulus exposure triggers the conditioned response of nausea and vomiting. Prevention of acute and delayed CINVs is the best approach for anticipatory CINVs so that a sensory stimulus is not established.
Antiemetics, including the new 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists, do not appear to control ANV and usually are managed with a variety of behavioural interventions as Progressive muscle relaxation with guided imagery, Hypnosis, Systematic desensitization, Electromyography and thermal biofeedback, Distraction via the use of video games… or using natural remedies like ginger.
Treating ANV with ginsix:
The active components of ginger Shogaols, gingerols and zingerone present in ginger may contribute to its therapeutic effect. An in
vivo study showed that 6-shogaol, 6-gingerol, and zingerone function as non-competitive antagonists of serotonin (5-HT3) receptors in visceral afferent neurons.
The active components of ginger inhibit the ion channel of the serotonin receptor by binding to a modulatory site, unlike 5-HT3 receptor antagonists such as ondansetron, which competitively inhibit the receptor at the serotonin recognition site. Studies that support how ginger can reduce nausea, suggest that it is the rhizome that contains the active ingredients. Both gingerol and shogaol compounds appear to affect gastrointestinal motility and the rate of gastric emptying, but they also affect neurotransmitters in the brain that can affect nausea.
Recommended use: 4 capsules a day, starting five days prior to the first chemotherapy session and continue during all the treatment.
Ginsix forte should be used as support for main oncological therapy. Never as a substitute and always under your doctor’s supervision
|Ginseng (Zingiber Officinalis
|Vitamin B6 (Pyridoxine HCL) 82.27%
*NRV: Nutritional Reference Value defined by Reg. CE 1169/2011. Theoretical values calculated on the basis of formulation. NRV calculated for the whole daily dose
Type 0 Capsules
Gelatine capsules weight 97 mg when empty and the hydroxypropylmethylcellulose capsules weight 95 mg when empty.
This capsule holds 400 to 805 mg of powder depending on the granulometry of the content.
Drawing from the 2012 study by Julie L. Ryan et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: A URCC CCOP study of 576 patients (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361530/) the recommended dose is four capsules per day, two capsules in each of the two main meals of the day (breakfast and dinner), start five days prior first chemotherapy session.
Consult with your doctor if you are taking:
Phenprocoumon (Marcoumar, others) interacts with GINGER
Phenprocoumon is used to slow blood clotting. Ginger can also slow blood clotting. Taking ginger along with phenprocoumon might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your phenprocoumon might need to be changed.
Warfarin (Coumadin) interacts with GINGER
Warfarin is used to slow blood clotting. Ginger can also slow blood clotting. Taking ginger along with warfarin might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Nifedipine (Procardia) interacts with GINGER
Taking ginger along with nifedipine might slow blood clotting and increase the chances of bruising and bleeding.
Losartan (Cozaar) interacts with GINGER. Ginger can increase how much losartan the body absorbs. Taking ginger along with losartan might increase the effects and side effects of losartan.