It is the first oral spray product for the reduction of acute symptoms in patients with mucositis in initial stages of grade I or II, helping to prevent progression to mucositis III/IV.
Main benefits of QUYRIUX ® ORALTOUCH SPRAY
- Helps reduce inflammation and promotes hydration of the oral mucosa.
- Relieves pain and burning sensation facilitating the intake of solids and liquids.
- Helps prevent the formation of ulcers and mouth sores.
- It is indicated for the prevention and treatment of xerostomia, since it moistens the dry mucosa and favour’s the secretion of saliva.
The clinical benefits of malic acid in improving xerostomia and consequently reducing the symptoms of mucositis, xerostomia and burning mouth syndrome, have been widely demonstrated:
In the study carried out by the Department/Institut: University of Murcia. Department of Dermatology, Stomatology, Radiology and Physical Medicine, demonstrated its effectiveness: 
In the study, the dry mouth questionnaire (DMQ) was used to assess the levels of dry mouth before and after the applicati
on of the product/placebo. Unstimulated and stimulated salivary flow rates were measured before and after application. DMQ scores increased significantly (improved dry mouth sensation) (P < 0.05) after application of 1% malic acid, while DMQ scores did not increase significantly after application of placebo (P > 0, 05). After two weeks of 1% malic acid application, resting and stimulated salivary flow rates increased significantly (P < 0.05). After application of the placebo product, the resting and stimulated salivary flow rates did not increase significantly (P > 0.05).
Similar conclusion by a study conducted in Chile. Many other studies evidence same results.
CONCLUSION: Topical application of 1% malic acid spray improved dry mouth sensation and increased resting and stimulated salivary flow rates in patients with xerostomia.
1 Gómez-Moreno G, Aguilar-Salvatierra A, Guardia J, et al. The efficacy of a topical sialogogue spray containing 1% malic acid in patients with antidepressant-induced dry mouth: a double-blind, randomized clinical trial. Depress Anxiety. 2013 Feb;30(2):137-42. doi:10.1002/da.22017 https://pubmed.ncbi.nlm.nih.gov/23124914/
2 Impact of 1% malic acid spray on the oral health-related quality of life of patients with xerostomia. Sven Niklander. Universidad Andrés Bello. Flavio Fuentes. Daniela Sanchez. A. VERONICA Araya. Hospital Clínico Universidad de Chile. June 2018. Journal of Oral Science 60(2):278-284. DOI:10.2334/josnusd.17-0164 https://pubmed.ncbi.nlm.nih.gov/29925712/
Sodium Bicarbonate and Saline Solution:
Sodium bicarbonate and saline solution, in the concentrations of QUYRIUX ORALTOUCH SPRAY, have proven effective in reducing the symptoms of patients with mucositis, being its basic treatment one of the great advantages of QUYRIUX ORALTOUCH SPRAY.
Studies that have examined the effectiveness of sodium bicarbonate on oral mucositis for this client group suggest that drugs with a 5% sodium bicarbonate base can be generally effective in the prevention and treatment of oral mucositis in cancer patients undergoing chemotherapy (Cabrera‐Jaimea, 2018) . A study by Cobra et al. (2018) showed that both 5% and 10% sodium bicarbonate solution are effective in preventing oral mucositis in cancer patients undergoing chemotherapy.
Consistent with the findings of the this study, Chitapanarux et al. (2018) stated although the highest incidence, severity and pain of oral mucositis were reported in the second week in patients with cancer under chemotherapy combined with radiotherapy, sodium bicarbonate mouthwash 5% reduces the incidence, severity and pain of oral mucositis in the third and fourth weeks (Chitapanarux et al., 2018). 
1 Cabrera‐Jaimea, S. (2018). Efficacy of plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: A feasibility randomised triple‐blind phase III clinical trial. European Journal of Oncology Nursing, 32, 40–47. 10.1016/j.ejon.2017.11.006 https://pubmed.ncbi.nlm.nih.gov/29353631/
2 Chitapanarux, I. , Tungkasamit, T. , Petsuksiri, J. , Kannarunimit, D. , Katanyoo, K. , Chakkabat, C. , Setakornnukul, J. , Wongsrita, S. , Jirawatwarakul, N. , Lertbusayanukul, C. , Sripan, P. , & Traisathit, P. (2018). Randomized control trial of benzydamine HCl versus sodium bicarbonate for prophylaxis of concurrent chemoradiation‐induced oral mucositis. Supportive Care in Cancer, 26, 879–886. 10.1007/s00520-017-3904-4 https://pubmed.ncbi.nlm.nih.gov/28942587/
Mint, with the scientific name (Mentha x piperita), is a genus of aromatic plants with more than 20 species and hundreds of varieties, including Mentha Piperita, the most widely used in phytomedicine, among the best known.
Mint contains phenolic acids, tannins, flavonoids, triterpenes and its essential oil is also applied to the skin or mucosa and is rich in menthol, a compound with toning and refreshing properties.
Benefits of Peppermint:
- Antiseptic: Mint extract has a germicidal action and is antiseptic, that is, it acts by reducing the formation of bacterial plaque in the mouth without causing irritation, damage or itching.
- Antimicrobial: Mint reduces the formation of bacteria, prevents bacterial colonies from proliferating, its penetrating aroma refreshes the mouth.
- Purifying: Contributes to a deep hygiene of the gums, tongue and oral mucosa.
- Refreshing: the menthol aroma and the compounds it possesses give products with Mint a pleasant sensation of freshness and calm when used, which is also long-lasting.
- Alonso, J. (1998). Tratado de Fitomedicina. Bases Clínicas y Farmacológicas. Madrid: ISIS.
- Bruneton, J. (1991). Elementos de Fitoquímica. Acribia.
- Sánchez, E.; García, D.; Carballo, C.; Crespo, M. (1996). «Estudio farmacognóstico de Mentha piperita L. (toronjil de menta)». Revista cubana de plantas medicinales 1 (3). pp. 40–45 . http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47961996000300009
- AA. (1975). Pharmacopée Européenne. Maisonneuve. 3ª ed. https://www.scirp.org/(S(i43dyn45teexjx455qlt3d2q))/reference/ReferencesPapers.aspx?ReferenceID=834510
- Barbalho, Sandra. (2017). PROPERTIES OF MENTHA PIPERITA: A BRIEF REVIEW. World Journal of Pharmaceutical and Medical Research. https://www.researchgate.net/publication/317290799_PROPERTIES_OF_MENTHA_PIPERITA_A_BRIEF_REVIEW
Coconut oil has some very interesting and beneficial properties for patients with mucositis:
- It has antifungal and antibacterial properties.
- It has activity to reduce inflammation of the gums and the oral and esophageal mucosa.
- Action to prevent and treat opportunistic infections.
Medical evidence found in a study that concludes: Oil pulling with coconut oil can be used as an alternative therapy to magic mouthwash for treating chemoradiation induced oral mucositis. 
Coconut oil pulling is very effective on severity of oral mucositis among cancer patients in treating and healing oral mucositis by which the standard and life of the cancer patients will be promoted. 
1 Saher F, Hosein M, Hasan A, Qureshi JA J, Amber T, Sunderjee NF. Effects of oil pulling on chemoradiotherapy induced oral mucositis in head and neck cancer patients. J Pak Dent Assoc 2019;28(1):03-12. DOI: https://doi.org/10.25301/JPDA.281.3 https://www.researchgate.net/publication/331007311_Effects_of_Oil_Pulling_On_Chemo-radiotherapy_Induced_Oral_Mucositis_in_Head_and_Neck_Cancer_Patients
2 Chinna Chadayan. Effectiveness of coconut oil pulling on oral mucositis among cancer patients in a selected hospital at Madurai. May 2020International Journal of Applied Research in Bioinformatics. DOI:10.6084/m9.figshare.14769189.v1 https://www.researchgate.net/publication/344450285_EFFECTIVENESS_OF_COCONUT_OIL_PULLING_ON_ORAL_MUCOSITIS_AMONG_CANCER_PATIENTS_IN_A_SELECTED_HOSPITAL_AT_MADURAI