Key Studies and Articles on the Gut-Brain Axis

Research in the field of the gut-brain axis has significantly advanced in recent years, providing a deeper understanding of how the interaction between the gut and the brain influences health and disease. Below are some key studies and articles that have set guidelines in this area of research.

1. Gut–brain axis biochemical signaling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function – Arneth, B. (2018)
This study explores how intestinal dysbiosis can influence brain function and contribute to the development of psychiatric conditions such as schizophrenia and depression. It emphasizes the importance of intestinal microbes in biochemical signaling to the brain and how imbalances in the microbiota can have significant impacts on mental health.

2. Gut Microbiota-brain Axis – Wang, H. & Wang, Y. (2016)
A review addressing the bidirectional communication between the gut microbiota and the brain, highlighting the implications of this axis in brain protection and impairment. The article suggests that manipulating the gut microbiota could offer new avenues for preventing and treating neurological diseases.

3. Gut-Brain Axis in Gastric Mucosal Damage and Protection – Sgambato, D. et al. (2016)
It discusses the role of the gut-brain axis in the protection and damage of gastric mucosa, highlighting how signals sent from the brain can influence gastrointestinal health. This study demonstrates the clinical relevance of the gut-brain axis beyond neuropsychiatric diseases.

4. The Gut Microbiome Feelings of the Brain: A Perspective for Non-Microbiologists – Lerner, A. et al. (2017)
It offers an accessible overview of how the intestinal microbiome affects brain function and neuropsychiatric disorders. This article highlights the importance of the intestinal microbiota in regulating emotions and behaviors, providing a basis for future research in the field.

5. Neonatal Microbiome and the Gut–Brain Axis: Is It the Origin of Adult Diseases? – Soliman, Y. et al. (2018)
It examines how the interaction between the neonatal microbiome and the gut-brain axis may contribute to the pathophysiology of neuropsychiatric and chronic diseases in adulthood. The study underscores the importance of the early years of life in establishing a healthy microbiome to prevent future diseases.

6. The role of the gut-brain axis in depression and anxiety disorders – Trigo, M. (2021)
It explores the relationship between microbiota dysbiosis and psychiatric disorders, focusing on depression and anxiety. This article reinforces the idea that restoring the balance of the intestinal microbiota could be an effective strategy for treating these conditions.

7. The Mind-Gut Connection: How the Hidden Conversation Within Our Bodies Impacts Our Mood, Our Choices, and Our Overall Health. Dr. Emeran Mayer (2016) ISBN-13: 978-0062376558
To understand the fundamentals of the gut-brain axis, a key reference is the book “The Mind-Gut Connection” written by Dr. Emeran Mayer. This book provides a comprehensive insight into the interaction between the gastrointestinal system and the central nervous system, exploring how the communication between these two systems affects both physical and mental health.

These studies and articles are just a sample of the vast literature supporting the importance of the gut-brain axis in a wide range of health conditions. They underscore the potential of interventions targeting the intestinal microbiota and intestinal permeability as means to improve both mental and physical health.